abstract：:Although it is recognized that glycoprotein (GP) IIb-IIIa complexes are deficient in platelets in Glanzmann's thrombasthenia, little is known of the origin of the defect. We have examined the megakaryocytes in a bone marrow aspirate obtained from a thrombasthenia patient during surgery. Analysis of platelet proteins b...

journal_title：Thrombosis and haemostasis

authors： Hourdillé P,Fialon P,Belloc F,Namur M,Boisseau MR,Nurden AT

更新日期：1986-08-20 00:00:00

abstract：:By a method of counting single platelets in diluted whole blood, platelet aggregates were quantified ex-vivo. Four groups: 20 thrombotic patients, 10 non-thrombotic patients, 10 healthy old controls and 10 healthy young controls were included in the study. Using a 19 gauge needle, with and without tubing, venous blood...

journal_title：Thrombosis and haemostasis

authors： Saniabadi AR,Lowe GD,Madhok R,Spowart K,Shaw B,Barbenel JC,Forbes CD

更新日期：1986-08-20 00:00:00

abstract：:Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated th...

journal_title：Thrombosis and haemostasis

authors： Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

更新日期：1986-06-30 00:00:00

abstract：:Serum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal ph...

journal_title：Thrombosis and haemostasis

authors： Fiedel BA,Ku CS

更新日期：1986-06-30 00:00:00

abstract：:Wide variations in procoagulant properties, lipid composition and ultrastructure of five commonly used APTT methods have been demonstrated. Performance of the methods with a range of coagulation abnormalities has been ranked. Most of the reagents obtained a high score with one or more defects, but a low score with oth...

journal_title：Thrombosis and haemostasis

authors： Stevenson KJ,Easton AC,Curry A,Thomson JM,Poller L

更新日期：1986-04-30 00:00:00

abstract：:A factor VIII inhibitor has been found in a patient with an unusual combination of factor VIII-related properties. The inhibitor is directed specifically against the clotting activity (VIII:C) of the factor VIII complex. It behaves in a similar fashion to high responding inhibitors of factor VIII seen in haemophilia A...

journal_title：Thrombosis and haemostasis

authors： Taylor LD,Dean FL,Tiedemann K,Ekert H

更新日期：1986-04-30 00:00:00

abstract：:A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagul...

journal_title：Thrombosis and haemostasis

authors： Haverkate F,Koopman J,Kluft C,D'Angelo A,Cattaneo M,Mannucci PM

更新日期：1986-02-28 00:00:00

abstract：:Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

更新日期：1986-02-28 00:00:00

abstract：:A multicenter study of various types of von Willebrand's disease (vWD) was conducted in order to compare the different electrophoretic techniques used to evaluate von Willebrand factor multimers in plasma. Seven laboratories participated in the blind study of eight plasma samples from two healthy subjects and six vWD ...

journal_title：Thrombosis and haemostasis

authors： Mannucci PM,Abildgaard CF,Gralnick HR,Hill FG,Hoyer LW,Lombardi R,Nilsson IM,Tuddenham E,Meyer D

更新日期：1985-12-17 00:00:00

abstract：:It has been reported that lanosterol can sensitize isolated rat platelets to agonists such as ADP and thrombin (4). The purpose of this paper was to determine whether lanosterol had similar effects on human platelets and whether this was achieved by changes in membrane fluidity. Lanosterol did increase the sensitivity...

journal_title：Thrombosis and haemostasis

authors： Hassall DG,Bruckdorfer KR,Sulpice JC,Lutton C

更新日期：1985-12-17 00:00:00

abstract：:In the present research protein analysis on SDS-polyacrylamide gel electrophoresis (PAGE) has been used to study the glycoprotein pattern of the blood platelets of four members from a family affected by May-Hegglin anomaly. In order to characterize the glycoprotein fractions, lactoperoxidase-iodination and immunopreci...

journal_title：Thrombosis and haemostasis

authors： Ricci G,Manservigi R,Albonici L,Zavagli G,Cassai E

更新日期：1985-12-17 00:00:00

abstract：:Molsidomine and its active metabolite SIN-1 were examined in humans and animals for platelet suppressant and fibrinolytic activities. Following oral administration of molsidomine at doses of 6 or 15 mg/kg to rabbits, their blood platelets in PRP ex vivo required higher threshold concentrations of ADP, AA and thrombin ...

journal_title：Thrombosis and haemostasis

authors： Basista M,Grodzińska L,Swies J

更新日期：1985-12-17 00:00:00

abstract：:A robust two-way analysis of variance technique was applied to determine simultaneously the effects of method and thromboplastin on prothrombin time. A new approach to outlier detection for two-way analysis of variance was used. Focusing on the underlying error structure improved the uniformity of the grading procedur...

journal_title：Thrombosis and haemostasis

authors： Han Y,Lawson WB,Dodds WJ,Lawrence CE

更新日期：1985-10-30 00:00:00

abstract：:Platelet behaviour was studied throughout pregnancy in a group of women who remained normotensive and a group with essential hypertension (EHT). Women who developed pregnancy-induced hypertension (PIH) were also studied together with a group of non-pregnant female controls. We determined the sensitivity of platelets t...

journal_title：Thrombosis and haemostasis

authors： Morrison R,Crawford J,MacPherson M,Heptinstall S

更新日期：1985-10-30 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:Heparin cofactor II (HC II) is a heparin-dependent inhibitor of thrombin, distinct from antithrombin III (AT III). This study was designed to evaluate its metabolism in healthy subjects. Purified HC II was labelled with 125I by the lactoperoxidase-glucose oxidase technique. The biological activity of the HC II was unc...

journal_title：Thrombosis and haemostasis

authors： Sié P,Dupouy D,Pichon J,Boneu B

更新日期：1985-10-30 00:00:00

abstract：:In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transfe...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A,Gryglewski RJ,Domagala B,Dworski R,Basista M

更新日期：1985-08-30 00:00:00

abstract：:Components of the fibrinolytic system were studied in samples of plasma from 15 normal, young women and from 11 women taking oral contraceptives containing 30 micrograms ethinyl oestradiol and 150 micrograms levo-norgestrel. Fibrinolytic activity of euglobulins precipitated at pH 5.9 was higher than normal in the horm...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Kluft C

更新日期：1985-08-30 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:This study explores the effects on some hematological parameters of a low-dose aspirin regimen (50 mg/day) versus a conventional aspirin treatment with reported antithrombotic efficacy (324 mg/day), in patients with acute myocardial infarction. Fifteen patients were randomized into 3 equal groups receiving 50 mg or 32...

journal_title：Thrombosis and haemostasis

authors： De Caterina R,Giannessi D,Boem A,Bernini W,Battaglia D,Michelassi C,Dell'Amico F,L'Abbate A,Patrignani P,Patrono C

更新日期：1985-08-30 00:00:00

abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

journal_title：Thrombosis and haemostasis

authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

更新日期：1985-08-30 00:00:00

abstract：:The behavior of direct fibrinolytic (non-plasmin) proteinase activity and plasminogen-activator activity in the lung and spleen was investigated in rats after a single intravenous injection of bacterial endotoxin, and the influence of thrombin inhibitors on the effects of the endotoxin was assessed. The non-plasmin fi...

journal_title：Thrombosis and haemostasis

authors： Okamoto U,Nagamatsu Y,Horie N,Yamamoto J,Sasaki K

更新日期：1985-06-24 00:00:00

abstract：:This study compares the ability of unmodified and carbohydrate-modified forms of factor VIII/von Willebrand factor (FVIII/vWF) protein to bind to platelets in the presence of ristocetin or thrombin. Treatment of intact FVIII/vWF with alpha-D-neuraminidase results in more than 95% desialylation. Asialo FVIII/vWF retain...

journal_title：Thrombosis and haemostasis

authors： Goudemand J,Mazurier C,Samor B,Bouquelet S,Montreuil J,Goudemand M

更新日期：1985-06-24 00:00:00

abstract：:We performed experiments to determine whether endothelial cells synthesize phospholipid metabolites via the lipoxygenase pathway and whether these metabolites influence platelet/vessel wall interactions. Monolayers of cultured human endothelial cells were incubated with 14C-arachidonic acid and their cyclo-oxygenase a...

journal_title：Thrombosis and haemostasis

authors： Buchanan MR,Butt RW,Magas Z,van Ryn J,Hirsh J,Nazir DJ

更新日期：1985-06-24 00:00:00

abstract：:A fully representative and viable platelet population was isolated from the blood of 15 baboons by a multiwash procedure, and labelled with In-111-oxine. The recovery of the total platelet population in the circulation was 85% +/- 9. Mean platelet life span was 146 hr +/- 13. Correcting for plasma radioactivity (alway...

journal_title：Thrombosis and haemostasis

authors： Kotzé HF,Lötter MG,Badenhorst PN,Heyns AD

更新日期：1985-06-24 00:00:00

abstract：:Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation products might play an important role in regulating fibrinogen synth...

journal_title：Thrombosis and haemostasis

authors： Princen HM,Moshage HJ,Emeis JJ,de Haard HJ,Nieuwenhuizen W,Yap SH

更新日期：1985-04-22 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:Seven mouse monoclonal antibodies have been produced against human melanoma tissue plasminogen activator (t-PA). They were specifically bound to 125I t-PA but not 125I urokinase (u-PA) and inhibited t-PA, but not u-PA, activity in plasminogen-rich 125I fibrin wells. Three of the antibodies directly inhibited the amido...

journal_title：Thrombosis and haemostasis

authors： MacGregor IR,Micklem LR,James K,Pepper DS

更新日期：1985-02-18 00:00:00

abstract：:The binding properties of purified bovine fibrinogen to bovine aortic endothelial cells have been examined in a tissue culture system. Endothelial cells bound 125I-fibrinogen in a calcium dependent fashion. Removal of calcium by EDTA instantaneously detached most of the cell-associated fibrinogen. Binding of fibrinoge...

journal_title：Thrombosis and haemostasis

authors： Delvos U,Preissner KT,Müller-Berghaus G

更新日期：1985-02-18 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Plasminogen activator that is associated with the development of hypersensitivity granulomas (gPA) was partially purified from a saline soluble fraction of murine lepromas elicited in "resistant" mice, C57BL/6N. The gPA was shown to consist of two subspecies (23,000 and 48,000 in molecular weight) with essentially ide...

journal_title：Thrombosis and haemostasis

authors： Izaki S,Hibino T,Isozaki Y,Hsu PS,Izaki M,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:We have studied 155 subjects, 48 normals, 36 diabetics without complications, 44 with complications and 27 patients with macroangiopathy. beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) are elevated in the patients groups. There is no correlation between the plasma levels of beta-TG and the stages of either...

journal_title：Thrombosis and haemostasis

authors： Fritschi J,Christe M,Lämmle B,Marbet GA,Berger W,Duckert F

更新日期：1984-12-29 00:00:00

abstract：:Some correlations between plasma and platelet fatty acids (FA) were evaluated "ex vivo" in 94 normal subjects. The highest relationships between total FA from plasma and platelets were found for 18:1 (r = 0.74) and 18:2 (r = 0.67). Low correlations were obtained for free fatty acids (FFA). The most significant correla...

journal_title：Thrombosis and haemostasis

authors： Vallés J,Aznar J,Santos MT

更新日期：1984-12-29 00:00:00

abstract：:Clinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic fa...

journal_title：Thrombosis and haemostasis

authors： Matzner Y,Marx G,Drexler R,Eldor A

更新日期：1984-10-31 00:00:00

abstract：:The fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new...

journal_title：Thrombosis and haemostasis

authors： Korninger C,Lechner K,Niessner H,Gössinger H,Kundi M

更新日期：1984-10-31 00:00:00

abstract：:Thromboembolism remains a serious problem in patients with prosthetic heart valves. Previous studies documented a number of platelet abnormalities in such patients and correlated the occurrence of thromboembolic complications with short platelet survival. We have studied platelet survival and platelet aggregation in e...

journal_title：Thrombosis and haemostasis

authors： Al-Mondhiry H,Pierce WS,Richenbacher W

更新日期：1984-10-31 00:00:00

abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

journal_title：Thrombosis and haemostasis

authors： Wiman B,Csemiczky G,Marsk L,Robbe H

更新日期：1984-10-31 00:00:00

abstract：:The turnover of recombinant pro-urokinase (Rec-pro-UK), recombinant urokinase (Rec-UK) and natural urinary urokinase (Nat-UK) was studied in rabbits and in squirrel monkeys (Saimiri sciureus). Following intravenous injection, urokinase activity disappeared rapidly from the blood. The initial disappearance rate could b...

journal_title：Thrombosis and haemostasis

authors： Collen D,De Cock F,Lijnen HR

更新日期：1984-08-31 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

journal_title：Thrombosis and haemostasis

authors： Dix CJ,Hassall DG,Bruckdorfer KR

更新日期：1984-07-29 00:00:00